The Livedrive desktop software runs on Windows XP, Windows Vista and Windows 7. There is software available for Mac, as a tech preview.

The Livedrive web portal can be used by all of the major web browsers, including Internet Explorer 7 or later, Firefox 2 or later and Safari 3 or later. Some features on the web portal require recent versions of Java or Flash.

The Livedrive mobile portal can be used by most mobile web browsers, including Opera. There is dedicated support for iPhone and Blackberry users, and a dedicated iPhone app is coming soon.